Hoch

Publikationen

Hier finden Sie alle wissenschaftlichen Publikationen und Arbeiten bzw. Veröffentlichungen von Dr. Gerald Böhm aus der Zeit von 1988 bis 2007. Die PDF-Dateien stehen zum Download gemäß den jeweiligen Urheberrechten bereit.

A method for simultaneous quantification of amyloid-beta1-40, amyloid-beta1-42 and amyloid-beta oligomers in human plasma is described. The method consists of a combination of immunoprecipitation using specific antibodies against the different forms of amyloid-beta, and immobilization of the immunocomplexes to magnetic beads. Addition of fluorescence-labelled antibodies which recognize the specific antibodies to the amyloid-beta subsets allows the peptide/associates detection in the sample by flow cytometry. The clinical assay performance was tested using blood samples from Alzheimer disease's patients and control donors. A sensitivity of 70% and a specificity of 81% was achieved.

 
 
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